Case study 01
T cell Receptor Mimetics (TCRms)
Precision targeting of peptide-HLA by Athebody DARPin
Published partnerships: 3T Bioscience
Athebody DARPin based T cell engagers (TCE)
- Efficient and Rapid Selection: The Athebody® platform enables quick and precise selection of pHLA-specific T cell engagers.
- High Flexibility: Athebody® modalities are highly adaptable, facilitating their incorporation into various TCE formats.
- Manufacturability: Inherent high stability and simple architecture provide good prospects for efficient manufacturing of Athebody® DARPin based TCE.
Rigid-body binding mechanism
- Outstanding Affinity and Specificity: Achieved through the rigid body binding of Athebody® domains.
- “Quasi-Parallel” Binding: Rationalizes higher specific recognition of pHLA complexes.
- Exceptional Target Cell Specificity: Demonstrated specific killing of both high and low expressing pHLA tumor target cells.
What is your project?
We are looking forward to hearing your ideas how Athebody® DARPins can enable your projects and how you like to access it.