Case study 01

T cell Receptor Mimetics (TCRms)

Precision targeting of peptide-HLA by Athebody DARPin

Published partnerships: 3T Bioscience

Athebody DARPin based T cell engagers (TCE)
  • Efficient and Rapid Selection: The Athebody® platform enables quick and precise selection of pHLA-specific T cell engagers.
  • High Flexibility: Athebody® modalities are highly adaptable, facilitating their incorporation into various TCE formats.
  • Manufacturability: Inherent high stability and simple architecture provide good prospects for efficient manufacturing of Athebody® DARPin based TCE.
Rigid-body binding mechanism
  • Outstanding Affinity and Specificity: Achieved through the rigid body binding of Athebody® domains.
  • “Quasi-Parallel” Binding: Rationalizes higher specific recognition of pHLA complexes.
  • Exceptional Target Cell Specificity: Demonstrated specific killing of both high and low expressing pHLA tumor target cells.

What is your project?

We are looking forward to hearing your ideas how Athebody® DARPins can enable your projects and how you like to access it.

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